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Synthesis of Polysubstituted 5-Azaindoles via Palladium-Catalyzed Heteroannulation of Diarylalkynes

✍ Scribed by Calvet, Géraldine; Livecchi, Marion; Schmidt, Frédéric


Book ID
126236866
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
996 KB
Volume
76
Category
Article
ISSN
0022-3263

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Synthesis of 5-, 6- and 7-azaindoles via
✍ Feroze Ujjainwalla; Daniel Warner 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 214 KB

The palladium-catalyzed heteroannulation of internal alkynes using orthoaminoiodopyridine derivatives is described. This experimentally simple procedure, which employs a Pd(dppf)C12/LiCl/Na~CO 3 reagent system, allows rapid and reliable access to a structurally diverse range of 5-, 6-and 7-azaindole