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Synthesis of polysubstituted 1,4-dihydropyridines via three-component reaction

โœ Scribed by Saeed Balalaie; Leila Baoosi; Fatemeh Tahoori; Frank Rominger; Hamid Reza Bijanzadeh

Book ID
118162140
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
526 KB
Volume
69
Category
Article
ISSN
0040-4020

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A New Three-Component Domino Synthesis o
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Solid-phase synthesis of 4-aryl-1,4-dihy
Solid-phase synthesis of 4-aryl-1,4-dihydropyridines via the Hantzsch three component condensation
โœ J.Guy Breitenbucher; Gina Figliozzi ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 159 KB

We report the synthesis of 1,4-dihydropyridines on solid support utilizing the Hantzsch condensation. Unwanted reactive impurities were removed from the desired products, by selective cleavage from solid support. The synthesis of a 272 compound library is reported using the methods described.

An efficient one-step synthesis of 1,4-d
An efficient one-step synthesis of 1,4-dihydropyridines via a triphenylphosphine-catalyzed three-component Hantzsch reaction under mild conditions
โœ Abdelmadjid Debache; Wassima Ghalem; Raouf Boulcina; Ali Belfaitah; Salah Rhouat ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 293 KB

a b s t r a c t An efficient one-step synthesis of 1,4-dihydropyridines in good to excellent yields via the triphenylphosphine-catalyzed Hantzsch three-component reaction of an aromatic aldehyde, ethyl acetoacetate and ammonium acetate is described.