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Synthesis of Polyphosphorylated AZT Derivatives for the Development of Specific Enzyme Immunoassays

✍ Scribed by Brossette, Thierry; Faou, Anne Le; Goujon, Laure; Valleix, Alain; Créminon, Christophe; Grassi, Jacques; Mioskowski, Charles; Lebeau, Luc

Book ID
126925978
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
116 KB
Volume
64
Category
Article
ISSN
0022-3263

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Synthesis of haptens for the development of a solid-phase immobilized epitope-immunoassay (SPIE-IA) of AZT-TP
✍ Luc Lebeau; Thierry Brossette; Laure Goujon; Christophe Créminon; Jacques Grassi 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 238 KB

The synthesis of the reduced form of AZT-triphosphate, Y-amino-Y-deoxythymidine-5'-triphosphate, and of its stable analog, 3'-amino-3'-deoxythymidine-5'-(~:~,~bis-methylene)triphosphate, is described. AMT-TP and AMT-PCPCP were prepared to develop a specific immunometric assay for AZT-TP.