The g-hydroxyketones 7.20, and 22 were prepared by stemocomrolled aldol reactions of (S)-and (N-18 with the enal 8. Acetmide hydrolysis gave the bicyclic acetals 23-2g, while tbe benxoate 26 gave the tetmhydropyran 6, corresponding to an A-ring subunit for 2-epi~mycin.
Synthesis of polyether carboxylic acids with a benzodioxinic subunit
β Scribed by P. Bosseray; G. Guillaumet; G. Coudert; H. Wassermann
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 200 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Carboxylic acids react with 2 equivalents of diethyl phosphorocyanidate in the presence of triethylamine to give dicyanophosphates in good yields; these dicyanophosphates can be hydrolyzed easily to give homologated ~t-hydroxycarboxylic acids.
## Abstract Our aim to enlarge the ring of the crown type compound 1, using the two component dilution principle, leads to hitherto unknown macrocycles **6** and **7**.
by basic hydrolysis is the standard method to prepare cyclopropene carboxylic acidst2). We have found, however, that if the cyclopropene resulting from the initial addition has a benzylic hydrogen adjacent to the ring, the alkaline hydrolysis condition lead instead to methylenecyclopropane acids. T