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Reaction of carboxylic acids with diethyl phosphorocyanidate; A novel synthesis of homologated α-hydroxycarboxylic acids from carboxylic acids

✍ Scribed by Masanori Mizuno; Takayuki Shioiri

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 139 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)02099-1

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✦ Synopsis

Carboxylic acids react with 2 equivalents of diethyl phosphorocyanidate in the presence of triethylamine to give dicyanophosphates in good yields; these dicyanophosphates can be hydrolyzed easily to give homologated ~t-hydroxycarboxylic acids.

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