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Synthesis of Phthalide Derivatives Using Nickel-Catalyzed Cyclization of o-Haloesters with Aldehydes

โœ Scribed by Dinesh Kumar Rayabarapu; Hong-Tai Chang; Chien-Hong Cheng


Book ID
101830755
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
126 KB
Volume
10
Category
Article
ISSN
0947-6539

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Pyrrolizidine and indolizidine skeletons were successfully constructed by nickel-catalyzed cyclization of 1,3-diene and aldehyde in a chain. A formal total synthesis of an Elaeocarpus alkaloid, (-)-Elaeokanine C, in the naturally occurring form was achieved using this cyclization.