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Synthesis of Photoaffinity Derivatives of Adenophostin A

✍ Scribed by Martin de Kort; Jaco Luijendijk; Gijs A. van der Marel; Jacques H. van Boom


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
401 KB
Volume
2000
Category
Article
ISSN
1434-193X

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The adenophostins exhibit approximately 10 ± 100 times higher receptor binding and Ca 2 mobilising potencies in comparison with the natural second messenger d-myo-inositol 1,4,5trisphosphate [Ins(1,4,5)P 3 ]. Despite many synthetic attempts to determine the minimal structural requirement for this un