Synthesis of Phosphocarnitine. -The reaction of (R)-epichlorohydrin (I) with phosphite (II) gives the phosphonic ester (III). The latter is transformed into the optically active phosphocarnitine salt (VII) by dealkylation, replacement of chloride with trimethylamine and ion exchange with potassium
✦ LIBER ✦
Synthesis of phosphocarnitine
✍ Scribed by Elżbieta Tadeusiak; Bożena Krawiecka; Jan Michalski
- Book ID
- 104260808
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 98 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Stereoselective synthesis of phosphocamitine has been achieved for the first time starting from R(-)epichlorohydrin.
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The authors regret that for the optically active phosphocarnitine potassium salt 2a the configuration should have been labelled (S). The structures in the Scheme are correct as drawn.
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