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Synthesis of phosphinic and phosphonic analogs of aromatic amino acids

โœ Scribed by A. V. Belyankin; A. R. Khomutov; Yu. N. Zhukov; O. N. Kartasheva; R. M. Khomutov


Publisher
Springer
Year
1997
Tongue
English
Weight
344 KB
Volume
46
Category
Article
ISSN
1573-9171

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Phosphonic and Phosphinic Acid Analogs o
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## Abstract Dialkyl phosphonates add in a 1,2 fashion to the C = N bond in 5,5โ€dimethylโ€3โ€thiozolines **2** to form dialkyl __rac__โ€(4โ€thiazolidinyl)phosphonates **3a** โ€“ **e**. Upon hydrolysis of **3a** __rac__โ€(1โ€aminoโ€2โ€mercaptoโ€2โ€methylpropyl)phosphonic acid (**4a**), the phosphonic acid analog