Synthesis of phosphinic acid transition state analogues for the reaction catalysed by kynureninase

✍ Scribed by Fiona C. Ross; Nigel P. Botting; Paul D. Leeson

• Book ID: 104364631
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 224 KB
• Volume: 6
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(96)00483-0

✦ Synopsis

The syntheses of phosphinic acid and methyl phosphinate analogues of kynurenine, designed as transition state mimics for the enzyme kynureninase are described, along with their inhibitory properties.