𝔖 Bobbio Scriptorium
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Synthesis of phenolically linked cyclic peptides

✍ Scribed by Michael J. Crimmin; Allan G. Brown

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
212 KB
Volume
31
Category
Article
ISSN
0040-4039

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✦ Synopsis

Cyclixation of a diary1 ether containing an or, m-amino acid residue leads to cyclic peptides which resemble the vancomycin binding pocket The glycopeptide antibiotics, exemplified by vancomycin, are believed to act by complexation with the car-boxy1 terminal of a pentapeptide unit which usually forms cross links in the bacterial cell wall'. This complexation has been shown in virro initially by the W experiments of Perkins2 and, more recently, by the

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