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Studies on cyclic peptides. II. Synthesis of cyclic peptides containing sarcosine

✍ Scribed by Toshiharu Sugihara; Yukio Imanishi; Toshinobu Higashimura

Publisher
Wiley (John Wiley & Sons)
Year
1975
Tongue
English
Weight
521 KB
Volume
14
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Cyclic peptides containing sarcosine, cyclo‐(Pro‐Sar‐Gly)~2~, cyclo‐(Sar‐Sar‐Gly)~2~, cyclo‐(Sar~4~), and cyclo‐(Sar~6~) have been synthesized by the cyclization of the p‐nitrophenyl ester of linear peptides. The tert‐butoxycarbonyl group was used as the N^α^‐protecting group, which was removed by acid. Benzyl ester was used to protect the C‐terminal. tert‐butoxycarbonylpeptide was obtained by the stepwise elongation of the peptide bond by the carbodiimide method. Deblocking and cyclization of the linear peptides gave the cyclic peptides.

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