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Synthesis of Phakellistatin 13 and Oxidation to Phakellistatin 3 and Isophakellistatin 3.

✍ Scribed by Kevin L. Greenman; Dana M. Hach; David L. Van Vranken


Book ID
101965220
Publisher
John Wiley and Sons
Year
2004
Weight
19 KB
Volume
35
Category
Article
ISSN
0931-7597

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✍ George F. Taylor; Stephen S. Thornton; C. Ray Tallent; John A. Kepler 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 677 KB

## Abstract 7‐Trietylsilylbaccatin III (11) was coupled with cis‐1‐benzoyl‐3‐triethylsiloxy‐4‐(3′‐bromophenyl)azetidin‐2‐one. Hydrolysis of the silyl groups gave 3″‐bromotaxol which was reduced with tritium gas to give[3″‐^3^H]taxol with specific activity of 19.3 Ci mmol. Reduction of 7‐triethylsil