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Synthesis of peptide derived amino alcohols II. Synthetic methodology for the preparation of tertiary alcohols

✍ Scribed by Jollie D. Godfrey Jr.; Eric M. Gordon; Derek J. Von Langen

Book ID: 104227137
Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 193 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)95370-x

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✦ Synopsis

Synthetic methods are described for the preparation of a series of tripeptide derived aminoalcohols (i.e., 2). These novel peptidyl tertiary alcohols are potential inhibitors of angiotensin converting enzyme (ACE). The synthetic targets resemble acyltripeptide substrates for the enzyme, but contain a -CHOH(CH3)-CHZ-NH-moiety, as replacement for the scissile amide bond.

Recently we described the design' and synthesis2 of a new series of tripeptide derived aminoalcohols, typified by structure L which were shown to be potent inhibitors of angiotensin converting enzyme (ACE).

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