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Synthesis of P-Chirogenic Diarylphosphinoacetic Acids and Their Proline Derivatives for Palladium-Catalyzed Allylic Alkylation Reactions.

✍ Scribed by Hubert Lam; Peter N. Horton; Michael B. Hursthouse; David J. Aldous; King Kuok Hii


Book ID
101981012
Publisher
John Wiley and Sons
Year
2006
Weight
18 KB
Volume
37
Category
Article
ISSN
0931-7597

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Synthesis of novel planar chiral ferroce
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We have shown that cymantrene derivatives are better P,N-chelate ligands for palladium-catalyzed allylic alkylation than ferrocenes, which have a similar pentagonal ligand structure to cymantrene derivatives. In particular, the PPh 3 -substituted cymantrene gave a higher enantioselectivity (>98%).