Synthesis of Oxygen Heterocycles via a Palladium-Catalyzed C-O Bond-Forming Reaction. -The first synthesis of cyclic aryl ethers by an intramolecular Pd-catalyzed ipso substitution of an aryl halide with an alcohol is described. This process is functional group tolerant and produces five-, six-, an
✦ LIBER ✦
Synthesis of Oxygen Heterocycles via a Palladium-Catalyzed C−O Bond-Forming Reaction
✍ Scribed by Palucki, Michael; Wolfe, John P.; Buchwald, Stephen L.
- Book ID
- 118136477
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 171 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0002-7863
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Catalytic amounts of Pd(OAc)2 in the presence of c-Bu4NC1, OMF and an appropriate Et3N) cyclize nitrogen-containing o-lodoaryl alkenes to indoles, quinolines, isoquinolines and isoquTnolones in short reaction times, under mild temperatures, and in high yields. Transition metal reagents have proven h