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Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents

โœ Scribed by Ganesha Rai; Craig J. Thomas; William Leister; David J. Maloney


Book ID
104096239
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
477 KB
Volume
50
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity.


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