Synthesis of optically active γ-lactones
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Yasutaka Shimotori; Yukihiko Nakahachi; Keita Inoue; Tetsuo Miyakoshi
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Article
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2007
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John Wiley and Sons
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English
⚖ 326 KB
## Abstract Both enantiomers of the six major kinds of __γ__‐lactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various __rac__‐__N__‐methyl‐4‐hydroxyalkanamides via Grignard reaction and the enantioselective acetylatio