Synthesis of Optically Active β-Amino Acid N -Carboxyanhydrides
✍ Scribed by Cheng, Jianjun; Ziller, Joseph W.; Deming, Timothy J.
- Book ID
- 125973200
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 108 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
The NCAs of the N-benzyl derivatives of 8-alanine, j3-nL-aminobutyric acid, and j3nkaminoisobutyric acid (nonplanar six-membered rings) were prepared by reacting the corresponding N-chloroformyl derivatives, obtained on reaction of the N-benzyl amino acids with phosgene, with triethylamine. Contrary
B-Amino acids2) are of great current interest because of their naturally occurring as the component of biologically active peptide antibiotics and also their structual relationship to the B-lactam, one of the most biologically important functional groups. We wish to describe here the catalytic asym