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Catalytic asymmetric synthesis of optically active β-amino acids

✍ Scribed by Kazuo Achiwa; Tsunehiko Soga

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
130 KB
Volume
19
Category
Article
ISSN
0040-4039

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✦ Synopsis

B-Amino acids2) are of great current interest because of their naturally occurring as the component of biologically active peptide antibiotics and also their structual relationship to the B-lactam, one of the most biologically important functional groups.

We wish to describe here the catalytic asymmetric hydrogenation of 8acetylamino acrylic acid derivatives (l_) using new bisphosphines, BPPM ($1 3) and BZPPM (3_dj4) as the chiral ligands, to give the optically active B-amino acids (2). BPPM-rhodium complex has been already demonstrated to be a quite effective catalyst for the synthesis of optically active a-amino acids 3) , isoquinoline alkaloid (salsolidine)5) , a-hydroxy esters6)and pantolactone ?

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