## Abstract Three syntheses of (2__S__, 3__R__)‐2,5‐dihydroxy‐3‐methylpentanoic acid (verrucarinic acid) and its derivatives suitably protected for the further transformation to macrocyclic trichothecenes are described. These involve an enantioselective ester hydrolysis by pig liver esterase, a __S
Synthesis of optically active verrucarinic acid derivatives
✍ Scribed by Barry M. Trost; Patrick G. McDougal
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 247 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Two new syntheses of verrucarinic acid (2__S__, 3__R__‐dihydroxy‐3‐methylpentanoic acid) and its derivatives, suitably protected for the further conversion to macrocyclic trichothecenes, are described. The first one makes use of a diastereoselective alkylation of a (−)‐(__S__)‐malic aci
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