Synthesis of optically active spiro-β-lactams by cycloadditions to α-alkylidene-β-lactams
✍ Scribed by Sven Anklam; Jürgen Liebscher
- Book ID
- 108378992
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 926 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Synthetically valuable cc-alkylidene-B-lactams are produced from the addition of chlorosulfonyl isocyanate to allenyl sulfides. Recently, several cr-alkylidene-B-lactams have been shown to be potent B-lactamase inhibitors. Included are the asparenomycins' (l), Ro 15-1903' (Z), and 6-r(L)-methoxymeth
## Abstract Substituted dihydropyrazole‐spiro‐β‐lactams and isoxazolidine‐spiro‐β‐lactam derivatives are regio‐ and stereoselectively prepared by 1, 3‐cydoadditions between substituted α‐methylidene‐β‐lactams and diazomethane, nitrones, or the __in__‐__situ__‐prepared dipoles ‘diphenylnitrilimine’
Spiroβ-lactams from α-Methylidene-β-lactams by Reactions with Diphenylnitrilimine, Acetonitrile Oxide, Nitrones, and Diazomethane. -Starting with the lactams (I) some β-lactams with a spiro(3,4) structure are synthesized by the title 1,3-cycloadditions. In the case of (Ia) the reaction gives the sa