✦ LIBER ✦

Synthesis of optically active penems - ii

✍ Scribed by V.M. Girijavallabhan; A.K. Ganguly; P. Pinto; R. Versace

Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 216 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)88129-0

No coin nor oath required. For personal study only.

✦ Synopsis

A chiral synthesis of P-thioxopenam, a highly useful synthon for penems, is described. S-ally1 penems undergo facile molecular rearrangements. Penems, first described by Woodwardl as a novel class of B-lactam antibiotics, have since been a center of attention' by virtue of their potency, broad-spectrum activity and stability to B-lactamases. We have reported earlier a chiral synthesis3 of penems, exemplified by sodium 5R, 6S, 8R-6 (1-hydroxyethyl)-2-ethylthio penem 3 carboxylate (Sch 294824), 101, 6306 (1979); b) M.

📜 SIMILAR VOLUMES

Synthesis of optically active penems

✍ V.M. Girijavallabhan; A.K. Ganguly; S.W. McCombie; P. Pinto; R. Rizvi 📂 Article 📅 1981 🏛 Elsevier Science 🌐 French ⚖ 227 KB

A general synthesis for optically active penems is described. Penems undergo a novel thermal isomerisation reaction. Won-classical B-lactams, exemplified by thienamycin', olivanic acidl and the Woodward's novel synthetic "penem" have all been described as potent antimicrobial agents. Recently, Sever

Asymmetric synthesis using α-sulfinylcar

Asymmetric synthesis using α-sulfinylcarbanions. II. Synthesis of optically active amines

✍ Gen-ichi Tsuchihashi; Shinobu Iriuchijima; Keiko Maniwa 📂 Article 📅 1973 🏛 Elsevier Science 🌐 French ⚖ 201 KB

Synthesis of Optically Active Biheliceno

Synthesis of Optically Active Bihelicenols.

✍ Daisuke Nakano; Rie Hirano; Masahiko Yamaguchi; Chizuko Kabuto 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 64 KB 👁 2 views

Synthesis of optically active hydroxypho

Synthesis of optically active hydroxyphosphonates

✍ Irina Guliaiko; Vitaly Nesterov; Sergei Sheiko; Oleg I. Kolodiazhnyi; Matthias F 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB 👁 1 views

## Abstract The reduction of dimenthyl ketophosphonates with sodium borohydride involves asymmetric induction at the α‐carbon atom, resulting in a small excess of the (R)‐enantiomer of the α‐hydroxyphosphonate formed. A higher ee purity was achieved if the reduction of chiral dimenthyl ketophosphon

Synthesis of optically active spirosulfu

Synthesis of optically active spirosulfuranes

✍ Péter Huszthy; István Kapovits; Árpád Kucsman; Lajos Radics 📂 Article 📅 1978 🏛 Elsevier Science 🌐 French ⚖ 255 KB

Synthesis of optically active biheliceno

Synthesis of optically active bihelicenols

✍ Daisuke Nakano; Rie Hirano; Masahiko Yamaguchi; Chizuko Kabuto 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 257 KB