Synthesis of optically active bihelicenols
β Scribed by Daisuke Nakano; Rie Hirano; Masahiko Yamaguchi; Chizuko Kabuto
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 257 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The reduction of dimenthyl ketophosphonates with sodium borohydride involves asymmetric induction at the Ξ±βcarbon atom, resulting in a small excess of the (R)βenantiomer of the Ξ±βhydroxyphosphonate formed. A higher ee purity was achieved if the reduction of chiral dimenthyl ketophosphon
A general synthesis for optically active penems is described. Penems undergo a novel thermal isomerisation reaction. Won-classical B-lactams, exemplified by thienamycin', olivanic acidl and the Woodward's novel synthetic "penem" have all been described as potent antimicrobial agents. Recently, Sever