𝔖 Bobbio Scriptorium
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Synthesis of oligopeptide and peptidomimetic libraries

✍ Scribed by Victor J Hruby; Jung-Mo Ahn; Subo Liao

Book ID
104414991
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
641 KB
Volume
1
Category
Article
ISSN
1367-5931

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✦ Synopsis

The elaboration of peptide libraries prepared by either chemical or biological methods in a format useful for discovery of peptides with specific biological activities was first introduced in the 1980s. A virtual explosion of activity in this area has occurred recently, and the basic approaches have been applied to a wide variety of chemistries and for all manner of biological, chemical and physical targets. Recent advances include new synthetic methodologies, new analytical methods, new design methods and new assay procedures.

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The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations
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A soluble peptidomimetic combinatorial library of 57,500 compounds was prepared. This library has a dipeptide scaffold with each amide hydrogen replaced with five different alkyl groups (methyl, ethyl, allyl, benzyl, or naphthylmethyl). Solid-phase methodology in combination with N-alkylation were u