Synthesis of Oligonucleotides Modified with Polyamines and Their Properties as Antisense and Antigene Molecules
β Scribed by Yoshihito Ueno; Akira Matsuda
- Book ID
- 101950523
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 51 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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For the first time a phosphorothioate oligoribonucleotide. namely PS-Cl4. has been synthesized on solid support. This modified oligomer is more resistant to enzymatic degradation than the corresponding rC14 and binds to complementary RNA strands. Various series of modified oligodeoxynucleotides hav
The 2-(1-methyl-4,5-dicyanoimidazolyl) group was attached to poly(diallylamine) and polyethylenimine, affording polymers containing an electron-withdrawing pendant group. The key to their preparation is high reactivity of 1-methyl-2-fluoro-4,5-dicyanoimidazole (1) toward nucleophilic aromatic substi