Multiply labelled d 8 -geranyl diphosphate (3-methyl-7-2 H 3 -methyl-[1,1,8,8,8]-2 H 5 -2E,6-octadienyl diphosphate) was synthesised from geraniol in 8 steps. Geraniol was converted to [1,1]-2 H 2 -geraniol by a three step oxidation-reduction sequence in 38% yield. Selective epoxidation of [1,1]-2 H
Synthesis of o-geranyl (1-thio)diphosphate
β Scribed by Douglas S. Mautz; V.Jo Davisson; C.Dale Poulter
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 244 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Absfmcr: O-Geranyl (1-thio)diphosphate was synthcsizcd from geraniol via H-phosphonate and thiophosphate intermediates in 5 steps with an overall yield of 20%.
Mono-, di-, and trithiophosphate analogues, especially of nucleosides, have become important tools in biochemistry
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## Abstract [10,10,10β^2^H~3~]β3, 7βDimethylβ2(E), 6βoctadienyl diphosphate ([10,10,10β^2^H~3~]geranyl diphosphate) was synthesized from 6β(benzyloxy)β4βmethylβ4(E)βhexenal by regioselective deuteration involving a modified Wittig reaction as the key step.
Prenyl, geranyl, and farnesyl derivatives containing nonionic surrogates for the diphosphate moiety, including disulfones 4-6 and 7-9, methylene disulfonamides 10-12, and carbamyl sulfamides 13-15, have been synthesized and evaluated biologically in an effort to find suitable nonlabile, neutral inhi
## Tritiated (E, E )-(2-diazo-3-trifluoropropionyloxy)geranyl diphosphate (DATFP-GDP) has been used as a photolabile analogue of (E,E)-farnesyl diphosphate (E,E-FDP) for an aid in isolating enzymes utilizing E,E-FDP as a substrate. We now report an alternative method of synthesizing this probe in