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Synthesis of nucleoside derivatives via heterocyclocondensation reactions

✍ Scribed by Vincent Kikelj; Paul Setzer; Karine Julienne; Jean-Claude Meslin; David Deniaud


Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
111 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis


A new synthesis of nucleoside analogues has been developed. The cyclocondensation of a glycosylated diazadiene or thiazadiene, with acyl chlorides or a-halogenoketones, respectively, resulted in good yields and excellent regioselectivities. We report an efficient method for the production of glucosyl pyrimidinones and glucosylamino thiazoles.


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