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Synthesis of Novel β-Lactone Inhibitors of Fatty Acid Synthase

✍ Scribed by Richardson, Robyn D.; Ma, Gil; Oyola, Yatsandra; Zancanella, Manuel; Knowles, Lynn M.; Cieplak, Piotr; Romo, Daniel; Smith, Jeffrey W.


Book ID
121089353
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
487 KB
Volume
51
Category
Article
ISSN
0022-2623

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Synthesis of novel α,α′,β-trisubstituted
✍ Christel Barbaud; Mohamed Guerrouache; Philippe Guérin 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 170 KB

A concise and efficient synthesis of a,a%,b-trisubstituted b-lactones is presented. These novel lactones are easily obtained in five steps and will be dedicated to anionic ring opening polymerization.