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Synthesis of Novel MKC-442 Analogues with Potent Activities against HIV-1

โœ Scribed by Nasser R. El-Brollosy; Erik B. Pedersen; Claus Nielsen


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
93 KB
Volume
336
Category
Article
ISSN
0365-6233

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โœ R. A. NUGENT; ET AL. ET AL. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 1 views

The effects of substituent modification on HIV-1 reverse transcriptase (RT) inhibitory activities of a series of pyrimidine derivatives, e.g. (I)-(IV), are studied. In comparison with reference compound delavirdine (DLV), compounds (Ia), (II), and (IIIa)-(IIIc) show the most potent in vitro inhibito