Synthesis of Novel Fluorinated Derivatives of 1,3-Dimethylbarbituric Acid. -Fluorinated derivatives of 5-benzylbarbituric acid are potentially interesting as anticancer and anti-AIDS agents. They are prepared using the Diels-Alder reaction of difluoro ketene aminal with compound (I), prepared by Kn
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Synthesis of novel fluorinated derivatives of 1,3-dimethylbarbituric acid
β Scribed by Yuelian Xu; William R Dolbier Jr.
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 481 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4020
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## Abstract This account concentrates on our new methodologies for the synthesis of fluorine analogues of amino acids and their derivatives using the Reformatskyβtype reactions of ethyl bromodifluoroacetate and ethyl dibromofluoroacetate with imines promoted by the Wilkinson catalyst. First, we pre