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Synthesis of novel flavonoid derivatives as potential HIV- Integrase inhibitors

✍ Scribed by Nelly N. Mateeva; Rao N. Kode; Kinfe K. Redda

Publisher
Journal of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
86 KB
Volume
39
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Eighteen novel flavonoid derivatives ‐ substituted chalcones and flavones were synthesized and characterized by using NMR, IR, UV/Vis spectroscopy and elemental analysis. The target compounds were achieved by using a sequence of simple and effective reactions starting from phloroglucinol. The initial hydroxyl groups were protected by methylation and in the final flavones the 5‐OH group was selectively demethylated by means of AlBr~3~. 5‐methoxy flavones exhibit a strong fluorescence, which was quenched after the removal of the methyl group.

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