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Synthesis of novel chiral binaphthyl phosphorus ligands and their applications in Rh-catalyzed asymmetric hydrogenation

✍ Scribed by Yongxiang Chi; Xumu Zhang

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 119 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00877-8

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✦ Synopsis

A series of new chiral mono-or bidentate phosphorus ligands were efficiently prepared through a key intermediate (S)-4-chloro-4,5-dihydro-3H-4-phosphacyclohepta[2,1-a;3,4-a%]binaphthalene and its derivatives. These ligands were applied in the Rh-catalyzed asymmetric hydrogenation of a-dehydro amino acids, enol acetates, itaconates, and enamides. Good to excellent enantioselectivities were obtained (up to 99.5% ee).

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