## Abstract New chiral aryl diphosphite ligands based on the pyranoside backbones of glucose and galactose were prepared. These ligands were tested in the Cuβcatalyzed asymmetric conjugate addition of diethylzinc to cyclic enones with up to 88% ee. The stereoselectivity was found to be dependent on
Synthesis of novel chiral bidentatephosphite ligands derived from the pyranoside backbone of monosaccharides and their application in the Cu-catalyzed conjugate addition of dialkylzinc to enones
β Scribed by Qing-Lu Zhao; Lai-Lai Wang
- Book ID
- 113929594
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 450 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0957-4166
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A series of new bulky monophosphite ligands were synthesized from axially chiral BINOL and highly sterically hindered adamantanecarbonyl chloride. These ligands were applied to the Cu-catalyzed asymmetric 1,4-conjugate addition of diethylzinc to cyclic enones and were found to have moderate enantios
A new class of chiral dinuclear ligands with phthalazine bridged bisoxazoline scaffold was designed and prepared in convenient synthetic routes. 1 H NMR analysis showed that this class of ligands could coordinate with two metal ions, either same or different. These ligands afforded good to excellent