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Chiral dinuclear phthalazine bridged bisoxazoline ligands: synthesis and application in enantioselective Cu-catalyzed conjugate addition of ZnEt2 to enones

✍ Scribed by Liang Zhang; Guoqiang Yang; Chaoren Shen; Sabah Arghib; Wanbin Zhang

Book ID: 104099006
Publisher: Elsevier Science
Year: 2011
Tongue: French
Weight: 593 KB
Volume: 52
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2011.02.098

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✦ Synopsis

A new class of chiral dinuclear ligands with phthalazine bridged bisoxazoline scaffold was designed and prepared in convenient synthetic routes. 1 H NMR analysis showed that this class of ligands could coordinate with two metal ions, either same or different. These ligands afforded good to excellent yields and enantioselectivities in Cu-catalyzed conjugate addition of ZnEt 2 to enones.

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