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Synthesis of Novel 3,5-Disubstituted-4-isothiazolecarbonitriles.

✍ Scribed by Manisha Mishra; S. K. Dutta Chowdhury; Kumar K. Mahalanabis


Publisher
John Wiley and Sons
Year
2004
Weight
19 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract The reaction of hydrazide with carbonyl chloride in the presence of sodium carbonates leads to the corresponding 1,2‐diacylhydrazines [**1a**–**t**, R^1^C(O)NHNHC(O)R^2^, R^1^ = aryl, R^2^ = aryl or alkyl] in moderate to excellent yield (57–90 %). The latter reacts with 2,4‐diphenyl‐1,3