A new approach for the synthesis of 3′-d
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Marija Prhavc; George Just*; Balkrishen Bhat; P.Dan Cook; Muthiah Manoharan
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Article
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2000
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Elsevier Science
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French
⚖ 94 KB
A stereoselective synthesis of 3%-deoxy-3%-C-formyl-5-methyluridine 2 is described via the dithiane 4 as the key intermediate. Compound 2 was coupled with 3 into a novel ribo-MMI dimer 1. The dimer was then incorporated into antisense oligonucleotides which were found to have high binding affinity t