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Synthesis of N,N′-disubstituted ureas from carbamates

✍ Scribed by Anwer Basha


Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
137 KB
Volume
29
Category
Article
ISSN
0040-4039

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A one pot selective mend N-alkylation of primary amides, thioamides, carbamates and ureas has been developed using aromatic and aliphatic aldehydes as alkylating agents and trifluoroacetic acid / triethylsilane as reagents. Application to an efficient synthesis of a primary amine from the correspond