Synthesis of new uracil non-nucleoside derivatives as potential inhibitors of HIV-1

✍ Scribed by Farag A. El-Essawy; Nasser R. El-Brollosy; Erik B. Pedersen; Claus Nielsen

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2003
• Tongue: English
• Weight: 58 KB
• Volume: 40
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570400203

✦ Synopsis

Abstract

6‐(2‐Phenylethyl) and 6‐cyclohexyl 5‐cyanouracils (1a,b) were synthesized and reacted with chloromethyl ethyl ether, benzyl chloromethyl ether, chloromethyl methyl sulfide and (2‐acetoxyethoxy)methyl bromide. New uracil analogues of (S)‐DHPA were synthesized by reaction of compounds (1a,b) with ((S)‐2,2‐dimethyl‐1,3‐dioxolane‐4‐yl) alkyl p‐toluenesulfonate.