Synthesis of new thienotriazolopyrimidine and thienopyrimidotetrazine derivatives from bifunctional intermediates
✍ Scribed by Maria Modica; Maria Santagati; Andrea Santagati
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2001
- Tongue
- English
- Weight
- 61 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
New compounds containing the thienotriazolopyrimidine and thienopyrimidotetrazine skeleton are prepared from the bifunctional intermediates 2,3‐diamino‐5,6‐dimethylthieno[2,3‐d]pyrimidin‐4(3__H__)‐one derivatives 13–17. The 2,3‐dihydro‐3‐substituted‐5,6‐dimethylthieno[2,3‐d]pyrimidin‐4(1__H__)‐one derivatives 8–12 are also prepared.
📜 SIMILAR VOLUMES
Reaction of 3 with (cyanomethylene)triphenylphosphorane in 8,9,10-trihydroxy-1-aza-6-oxaspiro[4.5]decane, which was identified as its peracylated derivative 16, was isolated. refluxing dichloromethane or methanol gave mixtures of 4a and 4b in ratios of about 3:1 and 1:3, respectively. The same Follo