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Synthesis of new spiro-[isothiochromene-3,5′-isoxazolidin]-4(1H)-ones

✍ Scribed by Brahim Bennani; Bouchra Filali Baba; Najib Ben Larbi; Abdelatif Boukir; Abdelali Kerbal; Mostafa Mimouni; Taibi Ben Hadda; Bartosz Trzaskowski; Abraham F. Jalbout


Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
401 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

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A series of seven new 2′,3′,4′‐substituted spiro[isothiochromene‐3,5′‐isoxazolidin]‐4(1__H__)‐ones (7‐13) has been prepared in the reaction of benzylidene(phenyl)azane oxide (5) or benzylidene(methyl)azane oxide (6) with (3Z)‐3‐(4‐substituted‐benzylidene)‐1__H__‐isothio‐ chromen‐4(3__H__)‐one (1‐4). The reaction occurs by a 1,3‐dipolar cycloaddition mechanism that leads to the regiospecific formation of various spiroisoxazolidines (7‐13).


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