## Abstract Tetrabromo-p-benzoquinone reacted with excess aromatic amines to give 2,5-dirylamino-3,6-dibromo-p-benzoquinones. The latter molecules on heating with sodium sulfide in alcohol in the presence of air gave triphenodithiazinediones. Heating with copper powder in nitrobenzene transformed t
Synthesis of new quinoxalinophenazinediones and tetrahydrobenzodipyrrolotetrones of biological interest
β Scribed by Ahmed S. Hammam; Mohamed S. K. Youssef; Ferial M. Atta; Thana A. Mohamed
- Book ID
- 111491125
- Publisher
- Versita
- Year
- 2008
- Tongue
- English
- Weight
- 263 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0366-6352
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β¦ Synopsis
Abstract
The reaction of two equivalents of sodium azide with diarylaminodibromo-p-benzoquinone (I) in DMF for 15β24 h produced quinoxalinophenazinediones together with a byproduct identified as diarylaminodiaminobenzoquinone. On the other hand, the reaction of bromanil with active methylenes, such as diethyl malonate and ethyl acetoacetate, resulted in disubstitution products which, on treatment with primary amines, cyclized into benzodipyrroletetrones. Comparative antifungal and antibacterial studies were made.
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## Abstract Indazoles and pyrazoles are known to be pharmaceutically relevant molecules. In particular their application as both analgesic and antitumoral drugs has been reported. In order to investigate the properties of compounds belonging to these families, we have synthesised new cycloalkylpyra