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Synthesis of new quinoxalinophenazinediones and tetrahydrobenzodipyrrolotetrones of biological interest

✍ Scribed by Ahmed S. Hammam; Mohamed S. K. Youssef; Ferial M. Atta; Thana A. Mohamed


Book ID
111491125
Publisher
Versita
Year
2008
Tongue
English
Weight
263 KB
Volume
62
Category
Article
ISSN
0366-6352

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✦ Synopsis


Abstract

The reaction of two equivalents of sodium azide with diarylaminodibromo-p-benzoquinone (I) in DMF for 15–24 h produced quinoxalinophenazinediones together with a byproduct identified as diarylaminodiaminobenzoquinone. On the other hand, the reaction of bromanil with active methylenes, such as diethyl malonate and ethyl acetoacetate, resulted in disubstitution products which, on treatment with primary amines, cyclized into benzodipyrroletetrones. Comparative antifungal and antibacterial studies were made.


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