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Synthesis of new polysubstituted (pyrazoles, pyrimidines and quinolines) five and six-membered heterocycles: reaction of α,α-dioxoketene dithioacetals with nucleophiles

✍ Scribed by M.A. Ebraheem; K.M. Lokanatha Rai; N.U. Kudva.N; A.S. Bahjat

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
529 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

A novel synthesis of polysubstituted pyrazoles 3a-d, pyrimidines 4a-f and quinolines 5a-c via the reaction of a,a-oxoketene dithioacetals 2a-c with hydrazine hydrate, malonohydrazide, urea, thiourea and aniline is reported and the synthetic potential of the method is demonstrated. The structure of the new compounds was established upon their elemental analysis, IR, 1 H NMR and 13 C NMR.

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