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Synthesis of New Polysialic Acid Derivatives

✍ Scribed by Yi Su; Cornelia Kasper; Andreas Kirschning; Gerald Dräger; Silke Berski

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
292 KB
Volume
10
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

In this paper we report the first synthesis of novel polysialic acid derivatives which is initiated by treatment of polysialic acid with EDC‐HCl to yield the inter‐residual δ‐lactone. Subsequent reaction with amines or hydrazine gives the corresponding polysialic acid amides and hydrazide. Alkylation of the tetrabutylammonium salt of polysialic acid yields polysialic acid esters. In contrast a variety of N‐derivatives of polysialic acid can be prepared starting from deacetylated polysialic acid. The N‐derivatives prepared in this communication can be used for the Cu‐catalyzed as well as Cu‐free “click” chemistry.
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