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Role of polysialic acid in peripheral myelinated axons

✍ Scribed by Carratù, M.R.; Steardo, L.; Cuomo, V.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
358 KB
Volume
34
Category
Article
ISSN
1059-910X

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✦ Synopsis

Polysialic acid (PSA), generally lost from the vertebrate nervous system during maturation, may regulate developmental differences in axon growth, bundling, and sprouting. Changes in polysialic levels on the axon surface seem to be involved during development in establishing normal pattern of muscle innervation. Besides the well-established role of PSA as a regulator of cell-cell interactions during development, PSA expression in myelinated axons may be related to reparative events in response to chemically induced injuries. Histochemical staining method using lectins with well-characterized binding specificities shows that glycoconjugates of the node of Ranvier undergo a rearrangement during exposure to 2,5-hexanedione, known to induce a peripheral neuropathy characterized by giant axonal swelling and retrograde demyelination. In particular, neutral glycoproteins with terminal galactose are replaced by sialoglycoproteins, consistent with the proposed role of PSA as a regulator of axonal behaviour during regeneration. o 1996 Wiley-Liss, Inc.

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