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Synthesis of new bergenin derivatives as potent inhibitors of inflammatory mediators NO and TNF-α

✍ Scribed by Muhammad Raza Shah; Mohammad Arfan; Hazrat Amin; Zahid Hussain; Muhammad Irfan Qadir; M. Iqbal Choudhary; Donald VanDerveer; M. Ahmed Mesaik; Samreen Soomro; Almas Jabeen; Inam Ullah Khan


Book ID
113496753
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
410 KB
Volume
22
Category
Article
ISSN
0960-894X

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A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-a