Synthesis and biological evaluation of novel series of chalcone derivatives as inhibitors of cyclooxygenase and LPS-induced TNF-α with potent antioxidant properties
✍ Scribed by Babasaheb P. Bandgar, Baliram S. Hote, Nagesh A. Dhole, Rajesh N. Gacche
- Book ID
- 118777924
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 342 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1054-2523
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## Abstract Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (CH~2~) spacer between the alcohol moiety and carbonyl group of the classical six‐membered α‐hydroxylactone ring. This modification provides higher lactone stability and did not impair its acti