Synthesis and biological evaluation of β-chloro vinyl chalcones as inhibitors of TNF-α and IL-6 with antimicrobial activity

Design, synthesis and biological evaluat

Design, synthesis and biological evaluation of new thalidomide analogues as TNF-α and IL-6 production inhibitors

✍ Charlotte Chaulet; Cécile Croix; David Alagille; Sylvain Normand; Adriana Delwai 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 620 KB

Several thalidomide analogues were synthesized and compared to thalidomide and its more active analogue, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-α and interleukin (IL)-6 by LPS-activated peripheral blood mononuclear cell