Synthesis of New 5-Substituted Pyrimidine Acyclonucleosides.
β Scribed by Ahmed F. Khattab
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 16 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The synthesis of the first examples of Class II mesoionic thiazolopyrimidine acyclonucleosides (MTA) incorporating the 2,3βdihydroxypropyl moiety as the sugar simulator is described. First, 2βbromothiazole was reacted with excess 1βaminoβ2,3βpropanediol acetonide __via__ an aromatic nuc
## Abstract A number of __N__βsubstituted pyrimidine glycosides were synthesized by coupling reaction of the pyrimidine base with acetobromosugars followed by deprotection. The synthesized compounds were tested for their antiviral activity against Hepatitis B Virus (HBV). Plaque reduction infectivi