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Synthesis and antiviral activity of new substituted pyrimidine glycosides

✍ Scribed by Mahmoud M. M. Ramiz; Wael A. El-Sayed; Ezzat Hagag; Adel A.-H. Abdel-Rahman

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
192 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A number of N‐substituted pyrimidine glycosides were synthesized by coupling reaction of the pyrimidine base with acetobromosugars followed by deprotection. The synthesized compounds were tested for their antiviral activity against Hepatitis B Virus (HBV). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high anti viral activities. J. Heterocyclic Chem., (2011).

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